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What are the Best Cannabis Strains for Pain? plus more...

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PurpleSkyz

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What are the Best Cannabis Strains for Pain?
BAILEY RAHN

One of the most common applications for medical marijuana is pain, whether it’s inflammation, headaches, neuropathic pain, muscle soreness,spinal injury, fibromyalgia, or cramps. Patients have seen varying degrees of success with cannabis in treating various pain-related ailments, depending on the type of pain, the intensity, and the individual’s own physiology.
This guide is informed both by user-submitted strain reviews and chemical profile data, as certain cannabinoids and terpenes are known to have areas of specialization such as pain. Because every person’s experience is so nuanced, we recommend sampling several of these suggestions and maybe even experiment with them in different forms, like topicals, oils, or even transdermal patches. Smoking and vaporizing are great ways to get marijuana’s painkilling properties quickly, but read up on non-smoking consumption methods and cannabis concentrate alternatives to get an idea of the full spectrum of options available to you.
And remember — there are many adept pain slayers out there in the cannabis world. Use our Explorer’s symptom and condition filters to find out what else has worked for other patients, and check the “Availability” tab on their strain pages to see if they’re available at a shop near you!

1. Cannabis Strains That Help Treat Generalized Pain


All hail ACDC, one of the most effective painkilling strains out there due to its one-two punch of cannabinoids CBD and THC. As a general rule, cannabis strains with high amounts of both THC and CBD tend to make the best pain medicines, and there are plenty of high-CBD strains out there offering similar chemical profiles as ACDC.

Unfortunately, high-CBD strains are relatively new to the game and not all patients have access to them, especially those living in states without medical marijuana laws. Luckily, high-THC strains also offer pain relieving benefits, and many people find that heavy indicas such as Blackberry Kushare particularly skilled in the art of killing pain.

Browse more strains suitable for general pain.

2. Cannabis Strains That Help Treat Inflammation and Arthritis


Cerebrally-focused sativa strains aren’t typically a first choice for patients treating pain and inflammation, but Harlequin‘s high-CBD content makes it an exception. Its uplifting and clear-headed effects set it apart from heavier, more intoxicating options and make it a perfect choice for daytime medicating.


Also known as Blue Venom, Berry White, and White Berry, Blue Widow is a prolific hybrid cross between parent strains Blueberry and White Widow. Leafly user reviews praise Blue Widow for its anti-inflammatory qualities, and perhaps the reason for this is Blue Widow’s rich terpene profile that typically boasts high levels of caryophyllene, or it could be its heavy resin production which gives way to massive amounts of THC and other beneficial compounds.
Browse more strains suitable for inflammation and arthritis.

3. Cannabis Strains That Help Treat Headaches and Migraines


Purple Arrow hits the target somewhere between heavy pain relief and uplifting euphoria, making it a great choice for headache sufferers needing swift relief without the couchlock effects typical of indica varieties.

Headband hybrids are commonly described as “cerebral” with effects that go straight to the crown of your head. Blueberry Headband lives up to its name, delivering focused headache relief and a sweet berry flavor.

Browse more strains suitable for headaches and migraines.

4. Cannabis Strains That Help Treat Cramps


With effects that relax tension in both mind and body, Redwood Kush is known to deliver a woody forest aroma alongside hefty amounts of THC to help ease muscle cramping.


Dynamite is another high-THC indica strain that blows pain and cramping out of the water, but be wary: Dynamite is also known to incite the power of the Munchie Beast.
Browse more strains suitable for cramps.

5. Cannabis Strains That Help Manage Spinal Injury Pain


Cataract Kush is a heavy-hitting hybrid cross between powerhouse classicsLA Confidential and OG Kush. This strain’s potency may not be for the novice consumer, but it’s perfect for patients needing a strain that can expertly annihilate pain associated with spinal injury.

Descending from some of the earliest indicas of Afghanistan, Mazar I Sharif is a relentless painkiller with a potency you can see on her heavy blanket of crystal trichomes. Afghani indicas have a reputation for their high cannabinoid contents, so it isn’t hard to imagine that so many patients have found relief from stubborn pain in Mazar.

Browse more strains suitable for spinal injury.

Thanks to: https://medicalmarijuanaanewbeginning.com



  

PurpleSkyz

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Cannabidiol inhibits lung cancer cells

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

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Abstract

Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001-3 μM) elicited concentration-dependent ICAM-1 up-regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen-activated protein kinase. Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold at 3 μM, with significant effects already evident at 0.01 μM. ICAM-1 induction became significant after 2 h, whereas significant TIMP-1 mRNA increases were observed only after 48 h. Inhibition of ICAM-1 by antibody or siRNA approaches reversed the anti-invasive and TIMP-1-upregulating action of CBD and the likewise ICAM-1-inducing cannabinoids Δ(9)-tetrahydrocannabinol and R(+)-methanandamide when compared to isotype or nonsilencing siRNA controls. ICAM-1-dependent anti-invasive cannabinoid effects were confirmed in primary tumor cells from a lung cancer patient. In athymic nude mice, CBD elicited a 2.6- and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts, as compared to vehicle-treated animals, and an antimetastatic effect that was fully reversed by a neutralizing antibody against ICAM-1 [% metastatic lung nodules vs. isotype control (100%): 47.7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness.

Thanks to: https://medicalmarijuanaanewbeginning.com



  

PurpleSkyz

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Cannabis Superior to Drugs for Inflammatory Bowel Condition (Crohn’s Disease)


Contributing writer for Wake Up World
When drugs fail and surgery is the only remaining option on the horizon, cannabis may provide an effective and safe natural alternative intervention for the debilitating inflammatory bowel disease known as Crohn’s disease. 
Crohn’s disease is a debilitating inflammatory bowel disease that chronically affects the lining of the digestive tract and is usually resistant to conventional drug-based treatment. Even with treatment the condition generally progresses to the point where surgery is required in 70% of sufferers. Surgery, however, does not usually provide a cure, with 30% undergoing surgery seeing a recurrence of symptoms within three years, and 60% within 10 years.[1]
Given the poor prognosis of those diagnosed with Crohn’s disease, some with the condition have been known to experiment with natural alternatives. At GreenMedInfo.com we have gathered preliminary research on natural interventions for the condition, with probiotics, boswellia and curcumin (a turmeric polyphenol) at the top of the list. We have also spent a good deal of time reporting on research indicating that wheat is an inflammatory food to the digestive tract and therefore should likely be avoided by anyone with an inflammatory bowel condition.

One potential remedy for Crohn’s disease that we have not yet reported on is cannabis. Animal research already indicates that it can ameliorate colitis, an inflammatory condition of the colon. There is also an established role of cannabis within gastroenterology for the following conditions: “anorexia, emesis, abdominal pain, gastroenteritis, diarrhea, intestinal inflammation, and diabetic gastroparesis.”[2] Additionally, a retrospective observational study from 2011 found that 21 of the 30 patients who imbibed inhaled cannabis saw significant improvement, with patients requiring steroid treatment reduced from 26 to 4. [view the full PDF here]
These preliminary results set the groundwork for a new study investigating cannabis in Crohn’s patients published this month in the journal Clinical Gastroenterology and Hepatology and titled, “Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study.” [view the full PDF here]
In the new study — the first randomized, placebo-controlled, double-blinded study of its kind on the topic — researchers studied 21 patients (mean age 40) with Crohn’s disease who did not respond to drug therapy (steroids, immunomodulators, or anti-tumor necrosis factor-? agents). Patients were randomly assigned to be given cannabis, twice daily, in the form of cigarettes containing 115 mg of (THC) or placebo containing cannabis flowers from which the THC had been extracted.
The study participants were assessed during 8 weeks of treatment and 2 weeks thereafter and saw the following remarkable results:
Complete remission (CDAI score, <150) was achieved by 5 of 11 subjects in the cannabis group (45%) and 1 of 10 in the placebo group (10%; P = .43).A clinical response (decrease in CDAI score of >100) was observed in 10 of 11 subjects in the cannabis group (90%; from 330 ± 105 to 152 ± 109) and 4 of 10 in the placebo group (40%; from 373 ± 94 to 306 ± 143; P = .028).Three patients in the cannabis group were weaned from steroid dependency. Subjects receiving cannabis reported improved appetite and sleep, with no significant side effects. [emphasis added]
The authors concluded cannabis was a clinically effective intervention in 10 of 11 patients:
“Although the primary end point of the study (induction of remission) was not achieved, a short course (8 weeks) of THC-rich cannabis produced significant clinical, steroid-free benefits to 10 of 11 patients with active Crohn’s disease, compared with placebo, without side effects. Further studies, with larger patient groups and a nonsmoking mode of intake, are warranted.” [emphasis added]

How Does Cannabis Work?

The primary mechanisms through which cannabis exhibits healing properties in Crohn’s disease are its immunomodulatory and anti-inflammatory properties:
“Cannabinoids have a profound anti-inflammatory effect, mainly through the CB2 receptor 2]. Cell-mediated immunity was found to be impaired in] chronic marijuana users [6]. A potent anti-inflammatory effect of cannabis was observed in rodents [7]. Studying the functional roles of the endocannabinoid system in immune modulation reveals that it is involved in almost all major immune events. Cannabinoids shift the balance of proinflammatory cytokines and anti-inflammatory cytokines (towards the T helper cell type 2 profiles (Th2 phenotype and suppress cell-mediated immunity, whereas humoral immunity may be enhanced [8]. Therefore, cannabinoids may be used to treat various inflammatory conditions ,including rheumatoid arthritis.” [Source]
For more information on the myriad therapeutic properties of cannabis visit our cannabis research database.
Article References 
[1] http://www.ccfa.org/what-are-crohns-and-colitis/what-is-crohns-disease/crohns-treatment-options
[2] Naftali, T., Bar Lev, L., Yablekovitch, D. et al. Treatment of Crohn’s disease with cannabis: an observational study. Isr Med Assoc J. 2011; 13: 455–458
About the author:

Sayer Ji is the founder of GreenMedInfo.com – an open access, evidence-based resource supporting natural and integrative modalities. He is on the Board of Governors for the National Health Federation and Fearless Parent, a Steering Committee Member of the Global GMO-Free Coalition (GGFC), a reviewer at the International Journal of Human Nutrition and Functional Medicine. Since 2003, Sayer has also served as a patient advocate and an educator and consultant for the natural health and wellness field.
For more, visit GreenMedInfo.com and Facebook/GreenMedInfo, or sign up for GreenMedInfo’s free e-Newsletter.

Thanks to: https://medicalmarijuanaanewbeginning.com



  

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