OUT OF MIND
Would you like to react to this message? Create an account in a few clicks or log in to continue.
Latest topics
» Doctor Finds ‘Rectangles and Inverted Pyramids’ in Degraded mRNA
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 10:02 am by PurpleSkyz

» New Italian Leader Vows To Dismantle the ‘New World Order’
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 9:56 am by PurpleSkyz

»  DART strikes its asteroid, in 1st planetary defense test
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 9:38 am by PurpleSkyz

» UFO appears in official logo of US aviation intelligence office
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 9:22 am by PurpleSkyz

» The Gerbil Who Laughed at You
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 9:19 am by PurpleSkyz

» Putin Gives Edward Snowden Russian Citizenship: State Media
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 12:29 am by PurpleSkyz

» The Plandemic Nut: How a False Hydroxychloroquine Narrative Was Created, and Much More
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 12:27 am by PurpleSkyz

» Europe suffers horrifying 755% increase in Excess Deaths among Children since EMA approved COVID Vaccine for kids
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 12:22 am by PurpleSkyz

» Pro-Vaccine Cardiologist Now Calls for Immediate End to COVID Vaccines
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 12:14 am by PurpleSkyz

» CDC Has 4 Days to Release Data on COVID Vaccine Injuries Collected via V-safe App, Court Rules
New Treatment Discovered Causes Cancer to Self-Destruct EmptyToday at 12:10 am by PurpleSkyz

» Bill Gates Wants to Force Everyone to Live Off of His Synthetic Patent Pending Corn
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 10:03 am by PurpleSkyz

» Thanksgiving Supplies like Turkey, Eggs And Butter Will Be Extremely Low In The US
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:38 am by PurpleSkyz

» The Current Crime Wave Is Unlike Any Ever Experienced In America
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:31 am by PurpleSkyz

» McCarthy: ‘We’re Going to Repeal 87,000 IRS Agents’ on Day One of Republican Majority
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:28 am by PurpleSkyz

» What Was COVID-19? World War V
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:20 am by PurpleSkyz

» When Green Turns Brown – And Nobody Notices
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:16 am by PurpleSkyz

» “Green” Energy Is a Scam. It Isn’t MEANT to Work.
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:13 am by PurpleSkyz

» THE GREAT RESET: Pierre Teilhard de Chardin’s Transhumanism & The Cult Of The Fourth Industrial Revolution
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 9:09 am by PurpleSkyz

» “Unexplained Deaths” Becoming #1 Cause of Death in 2022 in Canada, Australia, and Europe
New Treatment Discovered Causes Cancer to Self-Destruct EmptyYesterday at 8:58 am by PurpleSkyz

» “A” Solution for the Masses Does Not Exist: Perceived Reality Is in Fact Only Theatre?
New Treatment Discovered Causes Cancer to Self-Destruct EmptySun Sep 25, 2022 2:43 pm by PurpleSkyz

»  Government Pushs a “Digital Dollar” So It Can Seize Assets at Will & Enslave Humanity
New Treatment Discovered Causes Cancer to Self-Destruct EmptySun Sep 25, 2022 2:40 pm by PurpleSkyz

» The Unvaccinated Have Won
New Treatment Discovered Causes Cancer to Self-Destruct EmptySun Sep 25, 2022 2:38 pm by PurpleSkyz

You are not connected. Please login or register

OUT OF MIND » HEALTH & MEDICAL INFO » HOLISTIC HEALING & MEDICAL INFO » New Treatment Discovered Causes Cancer to Self-Destruct

New Treatment Discovered Causes Cancer to Self-Destruct

Go down  Message [Page 1 of 1]

PurpleSkyz

PurpleSkyz
Admin

New Treatment Discovered Causes Cancer to Self-Destruct Shutterstock_536066272-luek-700x400-e1508371427425
New Treatment Discovered Causes Cancer to Self-Destruct, No Damage to Healthy Cells
October 19, 2017

New Treatment Discovered Causes Cancer to Self-Destruct 1-noveltreatme-e1508371241230
©️ Albert Einstein College of Medicine
This image depicts the structure of the BAX protein (purple). The activator compound BTSA1 (orange) has bound to the active site of BAX (green), changing the shape of the BAX molecule at several points (shown in yellow, magenta and cyan). BAX, once in its final activated form, can home in on mitochondria and puncture their outer membranes, triggering apoptosis (cell death).

Scientists at Albert Einstein College of Medicine have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue of Cancer Cell, was directed against acute myeloid leukemia (AML) cells but may also have potential for attacking other types of cancers.
“We’re hopeful that the targeted compounds we’re developing will prove more effective than current anti-cancer therapies by directly causing cancer cells to self-destruct,” says Evripidis Gavathiotis, Ph.D., associate professor of biochemistry and of medicine and senior author of the study. “Ideally, our compounds would be combined with other treatments to kill cancer cells faster and more efficiently-and with fewer adverse effects, which are an all-too-common problem with standard chemotherapies.”
AML accounts for nearly one-third of all new leukemia cases and kills more than 10,000 Americans each year. The survival rate for patients has remained at about 30 percent for several decades, so better treatments are urgently needed.
The newly discovered compound combats cancer by triggering apoptosis-an important process that rids the body of unwanted or malfunctioning cells. Apoptosis trims excess tissue during embryonic development, for example, and some chemotherapy drugs indirectly induce apoptosis by damaging DNA in cancer cells.
Apoptosis occurs when BAX-the “executioner protein” in cells-is activated by “pro-apoptotic” proteins in the cell. Once activated, BAX molecules home in on and punch lethal holes in mitochondria, the parts of cells that produce energy. But all too often, cancer cells manage to prevent BAX from killing them. They ensure their survival by producing copious amounts of “anti-apoptotic” proteins that suppress BAX and the proteins that activate it.
“Our novel compound revives suppressed BAX molecules in cancer cells by binding with high affinity to BAX’s activation site,” says Dr. Gavathiotis. “BAX can then swing into action, killing cancer cells while leaving healthy cells unscathed.”
Dr. Gavathiotis was the lead author of a 2008 paper in Nature that first described the structure and shape of BAX’s activation site. He has since looked for small molecules that can activate BAX strongly enough to overcome cancer cells’ resistance to apoptosis. His team initially used computers to screen more than one million compounds to reveal those with BAX-binding potential. The most promising 500 compounds – many of them newly synthesized by Dr. Gavathiotis’ team-were then evaluated in the laboratory.
“A compound dubbed BTSA1 (short for BAX Trigger Site Activator 1) proved to be the most potent BAX activator, causing rapid and extensive apoptosis when added to several different human AML cell lines,” says lead author Denis Reyna, M.S., a doctoral student in Dr. Gavathiotis’ lab. The researchers next tested BTSA1 in blood samples from patients with high-risk AML. Strikingly, BTSA1 induced apoptosis in the patients’ AML cells but did not affect patients’ healthy blood-forming stem cells.
Finally, the researchers generated animal models of AML by grafting human AML cells into mice. BTSA1 was given to half the AML mice while the other half served as controls. On average, the BTSA1-treated mice survived significantly longer (55 days) than the control mice (40 days), with 43 percent of BTSA1-treated AML mice alive after 60 days and showing no signs of AML.
Importantly, the mice treated with BTSA1 showed no evidence of toxicity. “BTSA1 activates BAX and causes apoptosis in AML cells while sparing healthy cells and tissues-probably because the cancer cells are primed for apoptosis,” says Dr. Gavathiotis. He notes that his study found that AML cells from patients contained significantly higher BAX levels compared with normal blood cells from healthy people. “With more BAX available in AML cells,” he explained, “even low BTSA1 doses will trigger enough BAX activation to cause apoptotic death, while sparing healthy cells that contain low levels of BAX or none at all.”
Plans call for Dr. Gavathiotis and his team to see whether BTSA1 will show similar effectiveness when tested on animal models of other types of cancer.
Medical Xpress

Thanks to: http://bendedreality.com



  

Back to top  Message [Page 1 of 1]

Permissions in this forum:
You cannot reply to topics in this forum