OUT OF MIND
Would you like to react to this message? Create an account in a few clicks or log in to continue.
Latest topics
» New Age Deceptions Parts 1&2
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 1:08 am by PurpleSkyz

» Nearly 700 Cases of Heart Disease in 12 to 17-Year-Olds After COVID Shots
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 1:04 am by PurpleSkyz

» German Study Finds Zero Healthy Children Between 5 and 18 Died From COVID
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 12:59 am by PurpleSkyz

» EPISODE 7 LINK
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 12:56 am by PurpleSkyz

» CDC-funded study: COVID shots have no effect on virus transmission
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 12:52 am by PurpleSkyz

» HUGE: Federal judge strikes down DOD claim that Pfizer’s EUA “vaccine” and Comirnaty are “interchangeable”
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 12:50 am by PurpleSkyz

» The Growing Specter of Compulsory Vaccination
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyToday at 12:47 am by PurpleSkyz

» The Insanely Dark Story Behind “Poltergeist” and its Young Star Heather O’Rourke
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:40 pm by PurpleSkyz

» Robot shocks with how human-like it is
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:26 pm by PurpleSkyz

» Melbourne, Australia — Dec 4th, 2021: Massive, Spirited Protest Against Medical Tyranny
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:19 pm by PurpleSkyz

» Biden admin agrees to pause COVID shot mandate for healthcare workers. Fact Is they had no choice!
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:13 pm by PurpleSkyz

» THE GREAT RESET: ‘Now Or Never’, The Great ‘Transition’ Must Be Imposed – By Alastair Crooke
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:07 pm by PurpleSkyz

» Two German Footballers Collapse ‘Suddenly & Unexpectedly’ During the Same Match
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 12:04 pm by PurpleSkyz

» 'Stick Your Vaccine Mandate Up Your A**' Anthem Spreads
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 11:54 am by PurpleSkyz

» The FDA Slaps Major Warning About Pfizer Drug as Vaccine Reactions Come Under Scrutiny
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 11:49 am by PurpleSkyz

» Burning triangular object flying over South Carolina
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 11:46 am by PurpleSkyz

» Researchers Afraid To Publish Vaccine Heart Inflammation Study & Risk Funding Loss From Big Pharma
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 11:39 am by PurpleSkyz

» One of Florida’s Biggest Hospital Systems Suspends All Covid Vaccine Mandates
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptyYesterday at 11:27 am by PurpleSkyz

» Research Determines Link Between Air Pollution and Mental Illness
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptySun Dec 05, 2021 11:15 am by PurpleSkyz

» CDC: No Record of Naturally Immune Transmitting COVID-19
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptySun Dec 05, 2021 11:00 am by PurpleSkyz

» Surprised? Pfizer, BioNTech Say Jab for New ‘Omicron’ Strain Ready in 100 days
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptySun Dec 05, 2021 10:55 am by PurpleSkyz

» Pacific Ocean garbage patch is immense plastic habitat
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  EmptySun Dec 05, 2021 10:50 am by PurpleSkyz





Holistic Alternative
Health Care
by Bridgette Lyn Dolgoff

CONTACT HERE TO SCHEDULE ONLINE SESSIONS
www.https://coe-llc.com

NEW ETSY SHOP FEATURING HERBAL SALVES

NOW MAKING A MEDICATED OIL FOR PEOPLE WHO HAVE PCR DAMAGE
www.https://coe-llc.com










Sway on Out Of Mind:
Sway's Website:
josuemercadoproductions.tk
Buy Me A Coffee:
PayPal:www.paypal.me/swaymerk CashApp:

You are not connected. Please login or register

OUT OF MIND » CHANGING ENVIRONMENT & NATURE » SCIENCE & TECHNOLOGY » BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells

BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells

Go down  Message [Page 1 of 1]

PurpleSkyz

PurpleSkyz
Admin

BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  019-dna-i-motif-structure-living-cells-0_1024

BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells
It's not just the double helix!
PETER DOCKRILL
23 APR 2018

For the first time, scientists have identified the existence of a new DNA structure never before seen in living cells.
The discovery of what's described as a 'twisted knot' of DNA in living cells confirms our complex genetic code is crafted with more intricate symmetry than just the double helix structure everybody associates with DNA – and the forms these molecular variants take affect how our biology functions.
"When most of us think of DNA, we think of the double helix," says antibody therapeutics researcher Daniel Christ from the Garvan Institute of Medical Research in Australia.
"This new research reminds us that totally different DNA structures exist – and could well be important for our cells."
The new DNA component the team identified is called the intercalated motif (i-motif) structure, which was first discovered by researchers in the 1990s, but up until now had only ever been witnessed in vitro, not in living cells.
Now, thanks to Christ's team, we know the i-motif occurs naturally in human cells, meaning the structure's significance to cell biology – which has previously been called into question, given it had only been demonstrated in the lab – demands new attention from researchers.
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  019-dna-i-motif-structure-living-cells-1
(Zeraati et al., Nat Chem, 2018)
If your only familiarity with DNA shapes is the dual helical spirals made famous by Watson and Crick, the configuration of the intercalated motif could come as a surprise.
"The i-motif is a four-stranded 'knot' of DNA," explains genomicist Marcel Dinger, who co-led the research.
"In the knot structure, C [cytosine] letters on the same strand of DNA bind to each other – so this is very different from a double helix, where 'letters' on opposite strands recognise each other, and where Cs bind to Gs [guanines]."
According to Garvan's Mahdi Zeraati, the first author of the new study, the i-motif is only one of a number of DNA structures that don't take the double helix form – including A-DNA, Z-DNA, triplex DNA and Cruciform DNA – and which could also exist in our cells.
Another kind of DNA structure, called G-quadruplex (G4) DNA, was first visualised by researchers in human cells in 2013, who made use of an engineered antibody to reveal the G4 within cells.
In the new study, Zeraati and fellow researchers employed the same kind of technique, developing an antibody fragment (called iMab) that could specifically recognise and bind to i-motifs.
In doing so, it highlighted their location in the cell with an immunofluorescent glow.
BREAKING: Scientists Have Confirmed a New DNA Structure Inside Human Cells  019-dna-i-motif-structure-living-cells-2
Artist's impression, overlaid on imaging of the iMab antibody (green) in the nuclei of cells (Chris Hammang)
"What excited us most is that we could see the green spots – the i-motifs – appearing and disappearing over time, so we know that they are forming, dissolving and forming again," says Zeraati.
While there's still a lot to learn about how the i-motif structure functions, the findings indicate that transient i-motifs generally form late in a cell's 'life cycle' – specifically called the late G1 phase, when DNA is being actively 'read'.
The i-motifs also tend to appear in what are known as 'promoter' regions – areas of DNA that control whether genes are switched on or off – and in telomeres, genetic markers associated with ageing.
"We think the coming and going of the i-motifs is a clue to what they do," says Zeraati.
"It seems likely that they are there to help switch genes on or off, and to affect whether a gene is actively read or not."
Now that we definitively know this new form of DNA exists in cells, it'll give researchers a mandate to figure out just what these structures are doing inside our bodies.
As Zeraati explains, the answers could be really important – not just for the i-motif, but for A-DNA, Z-DNA, triplex DNA, and cruciform DNA too.
"These alternative DNA conformations might be important for proteins in the cell to recognise their cognate DNA sequence and exert their regulatory functions," Zeraati explained to ScienceAlert.
"Therefore, the formation of these structures might be of utmost importance for the cell to function normally. And, any aberration in these structures might have pathological consequences."
The findings are reported in Nature Chemistry.

Thanks to: https://www.sciencealert.com



  

Back to top  Message [Page 1 of 1]

Permissions in this forum:
You cannot reply to topics in this forum