OUT OF MIND
Would you like to react to this message? Create an account in a few clicks or log in to continue.
Latest topics
» Bad-clown Rising - Take 5
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 5:30 pm by PurpleSkyz

» The Unvaccinated Are Looking Smarter Every Week
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 11:36 am by PurpleSkyz

» At Least Two Dozen Lawsuits Have Been Filed Demanding Ivermectin Be Given To COVID Patients
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:49 am by PurpleSkyz

» Police Unions in Major Cities Across America are Leading the Revolt Against Vaccine Mandates
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:46 am by PurpleSkyz

» Dead-Calm Weather Killing Renewable Energy ‘Transition’
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:41 am by PurpleSkyz

» Four Parasites Found in Pfizer and Moderna COVID Vaccines
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:36 am by PurpleSkyz

» Dark Journalist X-111: 2022 UFO Warning!
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:33 am by PurpleSkyz

» Final Messages – Part 1 – How the Mandates End
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyToday at 9:25 am by PurpleSkyz

» EUDRA Adverse Reaction Stats Through October 9th, 2021
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 11:43 am by PurpleSkyz

» OH GREAT THEY’RE PUTTING GUNS ON ROBODOGS NOW
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 11:24 am by PurpleSkyz

» The Needle and the Damage Done
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 11:08 am by PurpleSkyz

» William Shatner ‘overwhelmed by sadness’ while discussing spaceflight
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 3:18 am by PurpleSkyz

» Unearthed video shows Fauci, health experts discussing ‘China’ virus, global vaccines weeks before COVID hit
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 2:25 am by PurpleSkyz

» 138 Legislators From 38 States Sign “New Declaration Of Independence” – AZ State Sen. Wendy Rogers
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 2:16 am by PurpleSkyz

» FDA Delays Moderna for Young Teens Pending Investigation into Heart Inflammation Side Effect
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyYesterday at 2:12 am by PurpleSkyz

» WILLY MYCO'S $100,000.00 (100k) CHALLENGE TO ANJALI
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyFri Oct 15, 2021 7:30 pm by PurpleSkyz

» Tyson: 'when the aliens come, we'll all know'
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyFri Oct 15, 2021 12:05 pm by PurpleSkyz

» Mystery boom and unexplained rumblings freak out people in New Hampshire
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyFri Oct 15, 2021 11:58 am by PurpleSkyz

» Does The Sun Have An Evil Twin?
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyFri Oct 15, 2021 11:50 am by PurpleSkyz

» Australia Introduces $5000 Fines for the Unvaxxed
We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It EmptyFri Oct 15, 2021 11:39 am by PurpleSkyz

You are not connected. Please login or register

OUT OF MIND » HEALTH & MEDICAL INFO » HOLISTIC HEALING & MEDICAL INFO » We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It

We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It

Go down  Message [Page 1 of 1]

PurpleSkyz

PurpleSkyz
Admin

We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It

Posted by Lou on August 12, 2019


We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It Alzheimers-2

We May Finally Know What Causes Many Cases of Alzheimer’s, and How to Stop It
realfarmacy.com
Published here on Aug 11, 2019
 
Alzheimer’s disease is one of the most feared illnesses afflicting older adults. Just ask anyone over the age of 55 who has misplaced car keys whether they didn’t have a momentary fear it could be a first sign of the crippling slow decline associated with this disease.
Most of what Doctors diagnose as “dementia” is Alzheimer’s disease (about 70% of dementia cases). With our rapidly aging populations, Alzheimer’s has become the 5th leading cause of death in the U.S. As a result, many of us have witnessed the heartbreak and despair of watching a loved one’s progressive memory loss and brain function resulting in the eventual but often slow death of the person they once knew. We watch our family members disintegrate in slow motion before our eyes and pray that we never meet the same fate.
Throughout the years, a lot of Alzheimer’s research focused on how the characteristic amyloid deposits on the brain are formed and exploring the role of inflammation in the disease progression. These amyloid proteins form large sticky plaques on the brain and are a hallmark of the disease and an early indicator of Alzheimer’s.
But finally, after decades of scientific failure and billions of dollars spent in looking for a cure along with a 99% failure rate in drug treatment research, there is a bright ray of hope that may lead to a long-sought-after treatment.
For several years now, research has identified a relationship between gum disease in older patients and the presence of amyloid beta plaques characteristic of Alzheimer’s disease in the brains of its sufferers.Before this line of investigation, the chronic periodontal disease found in Alzheimer’s patients was often dismissed as merely the result of dementia for those who could no longer maintain good oral hygiene.
But, this periodontal disease connection intrigued an international team of scientists and they decided to take a more in-depth look at the role of gum disease in Alzheimer’s. And they have published some truly intriguing results.
It was a complex series of studies worked on by several groups of scientists. So I’m going to try and break it down for you: First, they analyzed cerebrospinal fluid (considered a “window” into brain infection) from 10 living patients diagnosed with probable Alzheimer’s disease. Then they isolated DNA from Porphyromonas gingivalis (Pg), the primary pathogen found in chronic periodontitis, matching it with the Pg that the researchers found in the patients’ saliva samples.2
Next, the researchers looked at the toxic enzymes produced by Pg called “gingipains,” and analyzed brain-bank samples from deceased people.  One team found that there were greater gingipain loads in the brains of people who died from Alzheimer’s disease than in the brains of people who had no diagnosis of dementia.3
This new information quickly led them to the conclusion that Pg “is not a result of poor dental care following the onset of dementia or a consequence of late-stage disease, but is an early event that can explain the pathology found in middle-aged individuals before cognitive decline.”2
Now for the fascinating part of the study. The team tested a molecular therapy already undergoing clinical trials on Alzheimer’s patients to see if the compound, called COR388, could inhibit the toxic action of gingipains in the brains of mice that had been orally infected with gingipains. They found that not only was there reduced bacterial load of Pg brain infection, COR388 also blocked amyloid beta production, and reduced neuroinflammation.
Overall this added up to more protection of neurons in the hippocampus—the part of the brain that controls memory and is damaged early in the development of Alzheimer’s.4
What Does This Mean For Everyday People?
Dr. Jan Potempa, an investigator based at the University of Louisville’s Department of Oral Immunology and Infections Disease who was part of the international team said, “We now have strong evidence connecting P. gingivalis and Alzheimer’s pathogenesis (the chain of events leading to the disease)…”
An even more critical aspect of this study is that there might be enormous potential for therapies that could change the course of the disease or even stop the progression of a disease that now seems to be strongly connected with this particular dental disease and bacteria.Researchers are now focusing on developing a compound like COR388 that can effectively block the debilitating effects of Pg in the brain.
Also, consider this, there is a link between gum disease and other conditions such as heart disease and diabetes. The research here is also not conclusive, but there is some evidence that suggests that there is a connection and more research is underway.
According to The Mayo Clinic5 :
“Gum disease (periodontitis) is associated with an increased risk of developing heart disease.”
“Poor dental health increases the risk of a bacterial infection in the bloodstream, which can affect the heart valves. Oral health may be particularly important if you have artificial heart valves.”
“Tooth loss patterns are connected to coronary artery disease.
“There is a strong connection between diabetes and cardiovascular disease and evidence that people with diabetes benefit from periodontal treatment.”
Bottom line: Though this line of investigation is still young and COR388 may not prove to be a magic bullet (or the only magic bullet) against Alzheimer’s disease, this research is very encouraging, and we will continue to update this article with any new studies. Until then, it certainly makes sense to maintain good oral hygiene practices (regular brushing and flossing) and visit a dentist regularly to catch gum disease as early as possible!

References
via Expand Your Consciousness
1Kamer AR et al. Periodontal disease associates with higher brain amyloid load in normal elderly. Neurobiology of Aging. 2014;36(2):627-33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399973/
2Dominy SS et al. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances. 2019. http://advances.sciencemag.org/content/5/1/eaau3333
3Yager J. Are Brains with Alzheimer Disease All Gummed Up? 8 February 2019. NEJM Journal Watch. https://www.jwatch.org/na48441/2019/02/08/are-brains-with-alzheimer-disease-all-gummed
4 The University of Louisville. School of Dentistry. New science details discovery of bacterial pathogen in brains of Alzheimer’s patients. January 2019. https://louisville.edu/dentistry/news/new-science-details-discovery-of-bacterial-pathogen-in-brains-of-alzheimer2019s-patients-and-possible-evidence-of-disease-causation
5 Heart disease prevention: Does oral health matter? – Mayo Clinic Online. https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/heart-disease-prevention/faq-20057986
Photo credit: Alzheimer’s disease has destroyed neurons in the right-hand brain above. Jessica Wilson/Science Photo Library

Thanks to Lou at: https://talesfromtheloublog.wordpress.com



  

Back to top  Message [Page 1 of 1]

Permissions in this forum:
You cannot reply to topics in this forum