COVID-19 and Blood Types: Higher Risk for Blood Type A, Lower Risk for Blood Type O
- Rh Negative Facts
March 18, 20200
As I have previously posted regarding a different coronavirus (SARS-CoV) , lower numbers for blood type O were expected:
Blood Type O more likely resistant to coronaviruses?
Though this older study isn’t about COVID-19, it still is interesting: Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SARS-CoV), an RNA virus. The original SARS outbreak in the winter of 2002 to 2003 infected >8,000 individuals worldwide, with a fatality rate of 10% (292). Like other human coronaviruses, SARS-CoV infects the mucosal epithelium, causing an acute respiratory illness often accompanied by gastroenteritis. In a Hong Kong outbreak, there was an apparent association between disease transmission and ABO type (293). An epidemiology study of 34/45 hospital workers who contracted SARS after exposure to a single index patient showed that most of the infected individuals (23/34) were non-group O individuals (groups A, B, and AB). Group O individuals … Continue reading
Now we have some specific data for the COVID-19 coronavirus.
People with blood type A show highest risk and people with blood type O lowest risk in the study.
From a translation:
The scientists concluded that there were significantly more blood type A holders among coronavirus than in the entire population and significantly fewer people with blood type 0 A detailed analysis revealed that people with blood type A have 20 % higher risk of infection than people without group A. People with blood type 0, on the other hand, have a 33 % lower risk of infection than people with other blood types. Additional analyses showed that neither age nor gender of patients affected this image.
Here is the study:
Relationship between the ABO Blood Group and the COVID-19 Susceptibility
The Abstract reads:
As for the Rh factor:OBJECTIVE To investigate the relationship between the ABO blood group and the COVID-19 susceptibility. DESIGN The study was conducted by comparing the blood group distribution in 2,173 patients with COVID-19 confirmed by SARS-CoV-2 test from three hospitals in Wuhan and Shenzhen, China with that in normal people from the corresponding regions. Data were analyzed using one-way ANOVA and 2-tailed χ2 and a meta-analysis was performed by random effects models. SETTING Three tertiary hospitals in Wuhan and Shenzhen, China. PARTICIPANTS A total of 1,775 patients with COVID-19, including 206 dead cases, from Wuhan Jinyintan Hospital, Wuhan, China were recruited. Another 113 and 285 patients with COVID-19 were respectively recruited from Renmin Hospital of Wuhan University, Wuhan and Shenzhen Third People’s Hospital, Shenzhen, China. MAIN OUTCOME MEASURES Detection of ABO blood groups, infection occurrence of SARS-CoV-2, and patient death RESULTS The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in 1775 COVID-19 patients from Wuhan Jinyintan Hospital. The proportion of blood group A and O in COVID-19 patients were significantly higher and lower, respectively, than that in normal people (both P < 0.001). Similar ABO distribution pattern was observed in 398 patients from another two hospitals in Wuhan and Shenzhen. Meta-analyses on the pooled data showed that blood group A had a significantly higher risk for COVID-19 (odds ratio-OR, 1.20; 95% confidence interval-CI 1.02~1.43, P = 0.02) compared with non-A blood groups, whereas blood group O had a significantly lower risk for the infectious disease (OR, 0.67; 95% CI 0.60~0.75, P < 0.001) compared with non-O blood groups.In addition, the influence of age and gender on the ABO blood group distribution in patients with COVID-19 from two Wuhan hospitals (1,888 patients) were analyzed and found that age and gender do not have much effect on the distribution. CONCLUSION People with blood group A have a significantly higher risk for acquiring COVID-19 compared with non-A blood groups, whereas blood group O has a significantly lower risk for the infection compared with non-O blood groups.
Do not expect data anytime soon, especially not from SE Asia where frequencies of Rh(D) negative individuals are very low.
Infections of viral origin and Rh(D) negative blood
RhD negative subjects have increased the risk of developing of certain heart diseases, respiratory diseases and some immunity and autoimmunity related diseases, for example rheumatoid arthritis. The general pattern suggests that RhD negative subjects could have problems with autoimmunity, could be more resistant to infections of viral origin and could be less resistant to infections of bacterial origin. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141362 Chikungunya Coronavirus Ebola Flu HIV The Plague
Generally speaking, when it comes to infections of viral origin, Rh(D) negative individuals tend to do quite well, but that hasn’t been confirmed for every type of infection, so please do not assume.
Also do not let this be an indicator for anything when it comes to personal safety. Do not change your protection behavior. Even if you have some form of resistance, it wouldn’t equal immunity, so with the right amount of exposure, you still would get infected.
Thanks to Mike at: https://www.rhesusnegative.net