Study linking mRNA Vaccines to Acute Coronary Syndrome

Study linking mRNA Vaccines to Acute Coronary Syndrome

Posted on April 13, 2023



By Dr Mercola (originally published: November 30, 2021)
Link to study in Circulation: https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.10712

Story at-a-glance

• Using the PULS cardiac test, researchers have found Pfizer and Moderna mRNA COVID shots dramatically increase biomarkers associated with thrombosis, cardiomyopathy and other vascular events following vaccination
  
• Pre- and post-injection PULS tests for 566 patients were compared. On average, their PULS scores went from an 11% five-year risk for acute coronary syndrome, to a more than double, 25%, five-year risk
  
• Those who got the injection for fear that COVID-19 might adversely affect their heart now face the grim reality that they’ve exchanged a potential risk for a more certain one
  
• Another paper details how the mRNA shot can cause thrombocytopenia (low platelet count) through a mechanism that involves the activation of platelets by antibodies against the spike protein (anti-spike antibodies)
  
• A mystery that remains to be solved is why only certain people with antibodies to the spike protein (anti-spike antibodies) go on to develop symptoms of platelet activation and thrombocytopenia. One hypothesis is that only a subset of the anti-spike antibodies formed after vaccination can activate platelets and cause thrombocytopenia
  

[…]
In a November 21, 2021, tweet, cardiologist Dr. Aseem Malhotra writes:¹

“Extraordinary, disturbing, upsetting. We now have evidence of a plausible biological mechanism of how mRNA vaccine may be contributing to increased cardiac events. The abstract is published in the highest impact cardiology journal so we must take these findings very seriously.”

The abstract he’s talking about is “mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: A Warning,” published in the November 16, 2021, issue of the journal Circulation.² (ACS is Acute Coronary Syndrome).

Cardiac Risk Warning

The PULS (Protein Unstable Lesion Signature) cardiac test³ is a simple blood test that detects unstable cardiac lesion rupture, one of the leading causes of heart attacks. As noted by the authors of that paper, this is “a clinically validated measurement of multiple protein biomarkers,” which include:

• IL-16, a proinflammatory cytokine
  
• Soluble Fas, an inducer of apoptosis
  
• Hepatocyte growth factor (HGF), a marker for chemotaxis of T-cells into epithelium and cardiac tissue
  

These and several other proteins are indicative of your immune system’s response to arterial injuries that can result in cardiac lesions. These lesions can become unstable, and if they rupture, they can lead to a heart attack.
We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination. ~ Circulation November 16, 2021
So, based on the levels of these biomarkers, the test gives you a score that predicts your 5-year risk, as a percentage chance, of developing acute coronary syndrome (ACS). Elevated levels raise your PULS score while levels below the norm lower it.

COVID-Jabbed Patients More Than Double Their ACS Risk

According to the authors of the Circulation report:⁴

“The score has been measured every 3-6 months in our patient population for 8 years. Recently, with the advent of the mRNA COVID 19 vaccines (vac) by Moderna and Pfizer, dramatic changes in the PULS score became apparent in most patients. This report summarizes those results.

A total of 566 [patients], aged 28 to 97, M:F ratio 1:1 seen in a preventive cardiology practice had a new PULS test drawn from 2 to 10 weeks following the 2nd COVID shot and was compared to the previous PULS score drawn 3 to 5 months previously pre- shot.

Baseline IL-16 increased from 35=/-20 above the norm to 82 =/- 75 above the norm post-vac; sFas increased from 22+/- 15 above the norm to 46=/-24 above the norm post-vac; HGF increased from 42+/-12 above the norm to 86+/-31 above the norm post-vac.

These changes resulted in an increase of the PULS score from 11% 5-year ACS risk to 25% 5-year ACS risk. At the time of this report, these changes persist for at least 2.5 months post second dose of vac.

We conclude that the mRNA vacs dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.”

As noted by Malhotra, this is indeed extraordinarily disturbing. Patients who received a two-dose regimen of mRNA more than doubled their five-year ACS risk, driving it from an average of 11% to 25%. Just imagine the shape our medical system and society at large will be in if 1 of every 4 people who got the two-dose regimen ends up with acute heart failure.

Vaccine-Induced Thrombocytopenia

In related news, a paper published in the journal Blood Advances reviews “SARS-CoV-2 Spike-Dependent Platelet Activation in COVID-19 Vaccine-Induced Thrombocytopenia.”⁶ Thrombocytopenia is the medical term for low platelet count.
The authors point out that following the rollout of the mRNA and DNA-based COVID shots, more than 150 cases of thrombocytopenia have been reported. The reference for that statistic is a March 9, 2021, paper in the American Journal of Hematology,⁷ and injuries are stacking up at breakneck speed.
As of November 12, 2021, there were 4,387 cases of thrombocytopenia reported to the U.S. Vaccine Adverse Events Reporting System (VAERS),⁸ so it’s far more frequent than what they’re stating. (There are also 9,332 reports of heart attacks, which we just discussed, and 13,237 reports of myopericarditis, i.e., inflammation of the heart and/or heart sack.⁹)
According to the authors, identifying the mechanism by which the shots cause thrombocytopenia would facilitate the development of a diagnostic test. Historically, heparin-induced thrombocytopenia has been diagnosed using a serotonin release assay (SRA).
Using SRA, a subset of critically ill COVID-19 patients have tested positive for platelet-activating immune complexes that can cause thrombosis. Other researchers have also showed IgG antibodies from critically ill COVID-19 patients can activate platelets, resulting in a thrombotic event.
Here, using a modified SRA, they discovered spike-dependent, platelet-activating immune complexes in a patient with vaccine-induced thrombocytopenia, suggesting the spike protein is the causative factor.
[…]

Potential Mechanism Identified

If you found the section quoted above to be too complex, here’s the take-home message: The mRNA shot may be causing an exceptionally low level of platelets through a mechanism that involves antibodies against the spike protein (anti-spike antibodies) resulting in depletion of platelets by activating them.
Platelets are specialized cells that stop bleeding, and they have ACE2 receptors, which is what the SARS-CoV-2 spike protein binds to. When the spike protein binds to the ACE2 receptor on the platelets, it activates them.
This platelet activation can lead to disseminated intravascular coagulation, i.e., a pathological overstimulation of your coagulation system that can result in abnormal, and life threatening, blood clotting, as well as thrombocytopenia (low platelet count) and hemorrhaging.
Doctors for COVID Ethics described this mechanism in a February 28, 2021, letter¹¹ to the European Medicines Agency (EMA). In that letter, they warned that, based on this mechanism, spike protein-based COVID shots are likely to cause blood clots, cerebral vein thrombosis and sudden death, which is precisely what we’ve been seeing ever since.
In essence, you basically end up with so many blood clots throughout your vascular system that your coagulation system is exhausted, hence the low platelet count. The low platelet count, in turn, is what allows for hemorrhaging (abnormal bleeding).
[…]

Via https://articles.mercola.com/sites/articles/archive/2023/04/13/covid-vaccine-acute-coronary-syndrome.aspx/
 


THANKS TO: https://stuartbramhall.wordpress.com/2023/04/13/study-linking-mrna-vaccines-to-acute-coronary-syndrome/